Serine/Threonine Protein Kinase Stk Is Required for Virulence, Stress Response, and Penicillin Tolerance in Streptococcus pyogenes
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چکیده
منابع مشابه
Serine/threonine protein kinase Stk is required for virulence, stress response, and penicillin tolerance in Streptococcus pyogenes.
Genes encoding one or more Ser/Thr protein kinases have been identified recently in many bacteria, including one (stk) in the human pathogen Streptococcus pyogenes (group A streptococcus [GAS]). We report that in GAS, stk is required to produce disease in a murine myositis model of infection. Using microarray and quantitative reverse transcription-PCR (qRT-PCR) studies, we found that Stk activa...
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BACKGROUND Serine/threonine kinases are involved in gene regulation and signal transduction in prokaryotes and eukaryotes. Here, we investigated the role of the serine/threonine kinase Stk in the opportunistic pathogen Staphylococcus epidermidis. METHODOLOGY/PRINCIPAL FINDINGS We constructed an isogenic stk mutant of a biofilm-forming clinical S. epidermidis isolate. Presence of stk was impor...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 2011
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.05360-11